Effect of Janus kinase (JAK) signaling inhibition on lineage plasticity and drug sensitivity in castrate resistant prostate cancer.
Zaidi S, Chan J, Love J, Zhao J, Setty M, Lawrence K, Gopalan A, Goodrich D, Morris M, Chen Y, Karthaus W, Pe'er D, Sawyers C. Effect of Janus kinase (JAK) signaling inhibition on lineage plasticity and drug sensitivity in castrate resistant prostate cancer. Journal Of Clinical Oncology 2023, 41: 227-227. DOI: 10.1200/jco.2023.41.6_suppl.227.Peer-Reviewed Original ResearchAndrogen receptor signaling inhibitorsFDA-approved inhibitorFibroblast growth factor receptorLineage plasticityProstate cancerAndrogen receptorInhibitors of JAK/STATSuccess of targeted cancer therapyCastration resistant prostate cancerSignaling inhibitorsLoss of tumor suppressor genesCases of prostate cancerFibroblast growth factor receptor signaling pathwayJanus kinaseSingle cell RNA analysisRadiologically guided biopsyResistant prostate cancerEffects of Janus kinaseIncreased androgen receptorTumor-derived organoidsGenetic editing toolsResistance to therapySingle cell RNA sequencingGrowth factor receptorTumor suppressor gene
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