2024
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024, 32: 126-144.e18. PMID: 39163853, PMCID: PMC11748234, DOI: 10.1016/j.chembiol.2024.07.011.Peer-Reviewed Original ResearchHuman aldo-keto reductase family 1 member C3Mammalian fatty acid synthaseDNA double-strand break responseDouble-strand break responseAldo-keto reductase family 1 member C3Associated with poor prognosisPolyamine pathwayFatty acid synthesisFatty acid synthaseAcid synthaseAKR1C3 activityPoor prognosisBiochemical roleAcid synthesisClinical significanceLigand screeningFerroptosis resistanceDNA damageAKR1C3Metabolic diseasesDiverse cancersDNANADPHAgonists of GPR84GPR84
2022
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9
Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. Nature Communications 2022, 13: 3811. PMID: 35778404, PMCID: PMC9249769, DOI: 10.1038/s41467-022-31596-7.Peer-Reviewed Original ResearchConceptsLung tumor growthIL-9Tumor growthAdoptive cell transfer therapyPulmonary interstitial macrophagesPotent anti-tumor activityLung cancer patientsCell transfer therapyLung tumor modelLung cancer therapyMultiple mouse modelsPotential therapeutic targetIL-9 signalingAnti-tumor activityPro-tumorigenic effectsAdoptive transferMacrophage axisPoor outcomePoor prognosisCancer patientsLung cancerArginase-1Interstitial macrophagesIL-9RInterstitial macrophage population
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