HLA tapasin independence: broader peptide repertoire and HIV control
Bashirova A, Viard M, Naranbhai V, Grifoni A, Garcia-Beltran W, Akdag M, Yuki Y, Gao X, O’hUigin C, Raghavan M, Wolinsky S, Bream J, Duggal P, Martinson J, Michael N, Kirk G, Buchbinder S, Haas D, Goedert J, Deeks S, Fellay J, Walker B, Goulder P, Cresswell P, Elliott T, Sette A, Carlson J, Carrington M. HLA tapasin independence: broader peptide repertoire and HIV control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 28232-28238. PMID: 33097667, PMCID: PMC7668082, DOI: 10.1073/pnas.2013554117.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenCytotoxic T cell responsesImmune responseHIV-1 proteomeT cell responsesTapasin dependenceEx vivo examinationHLA-ILeukocyte antigenViral loadInfected subjectsHIV-1Peptide presentationPeptide repertoireAllotypesIndependent progressionAbsence of tapasinPeptide loading complexTapasinAfrican AmericansPeptideAntigenResponse
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