On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
Cho B, Jung Y, DeMario V, Lau E, Podlasek S, Grant M, Gehrie E, Frank S. On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study. Transfusion 2019, 59: 2678-2684. PMID: 31121073, DOI: 10.1111/trf.15355.Peer-Reviewed Original ResearchConceptsUrgent reversalLabel useMortality rateFour-factor prothrombin complex concentrateAcute major bleedingVitamin K antagonistsProthrombin complex concentrate useProthrombin complex concentrateOff-label useCoagulation factor deficienciesHospital mortalityMajor bleedingK antagonistsPatient characteristicsClinical outcomesBlood utilizationExpensive treatment optionsLabel indicationsSingle institutionTreatment optionsComplex concentrateObservational studyFactor deficiencyInvasive proceduresOff label
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