Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery
Greenwood N, Boyer Z, Ellman J, Gnamm C. Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery. Journal Of Medicinal Chemistry 2025, 68: 4079-4100. PMID: 39787298, DOI: 10.1021/acs.jmedchem.4c02714.Peer-Reviewed Original ResearchConceptsFunctional groupsMedicinal chemist's perspectiveTraditional functional groupsChemistry toolboxMedicinal chemistryMedicinal chemistry toolboxDrug scaffoldsSulfilimineMetabolic stabilityChemist's perspectiveHNE inhibitorsDrug discoveryAnalog of imatinibPhysiologically relevant conditionsRelevant conditionsPharmacophoreChemistryPropertiesS(IVSolubilityIn vitro propertiesScaffolds
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