HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature
Vageli D, Doukas P, Georgiou D, Prokopiou M, Ladaki N, Papadopoulou A, Doukas S, Zacharouli K, Makaritsis K, Ioannou M. HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature. Frontiers In Bioscience-Landmark 2025, 30: 27004. PMID: 39862086, DOI: 10.31083/fbl27004.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorTreatment efficacyHIF-1aUpregulation of pro-inflammatory moleculesPotential biomarkersMitogen-activated protein kinaseAttenuation of atherosclerosis progressionOverexpression of vascular endothelial growth factorVascular endothelial growth factor protein expressionIncreased VEGFVascular endothelial growth factor overexpressionLipopolysaccharide-induced tumor necrosis factor-alpha factorAtherosclerosis progressionSystematic reviewTumor necrosis factor-alphaVascular smooth muscle cellsExposure to methamphetamineAdenosine receptor antagonistHypoxia-inducible factor-1 alphaNecrosis factor-alphaNitric oxideChronic exposure to methamphetamineEndothelial growth factorSmooth muscle cellsEvaluation of treatment efficacy
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